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pentobarbital will minimize the extent or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.pentobarbital will lessen the level or influence of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lower the extent or result of acalabru